UNIV - Research Specialist III - Surgery: Center for Cellular Therapy

Company: MUSC Health University Hospital
Location: Charleston
Posted on: January 25, 2023

Job Description:

Job Description Summary

The Department of Surgery is actively recruiting for a Research Specialist III for the Center for Cellular Therapy (CCT) at MUSC. This position will perform and lead junior technicians for all investigational cellular product derivation in the CCT. Major duties include leading immunomonitoring and other activities in the CCT; directly overseeing training and implementation of procedures and practices of current and future personnel, directly designing and implementing new projects that support the growth and business development of the facility with guidance from CCT scientific directors; assist the quality control director with product quality assurance, prepare project budget estimate and invoice for different projects as needed; together with other technicians, order and maintain reagents and supplies needed for each CCT projects.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type---

Classified

Cost Center

CC000957 COM Center For Cellular Therapy CC

Pay Rate Type

Salary

Pay Grade

University-06

Scheduled Weekly Hours

40

Work Shift

Job Description

Pay Band:

$41,778.00 - $59,538.50 - $77,299.00 (min - mid - max

Job Duties:

• Responsible for coordinating the receipt of patient samples by working closely with the Clinical Trial Coordinators. Work with cultures and various cell types including but not limited to mesenchymal stem cells, T cells, tumor-infiltrating lymphocytes, tumor cells, and dendritic cells. Standard Operating Procedures (SOPs) will be optimized, written and validated for ongoing and future products. Works with ELISA, EliSPOT, cytokine arrays, RNA extraction and RTPCR. Develop and optimize complex Flow Cytometry staining to monitor the immunologic effect of investigational new drugs where required. Process samples in a timely manner. Must maintain and teach current Good Manufacturing Practices (cGMP) and tissue culture techniques to other personnel. Data will be compiled and presented to CCT Program Director and Principal Investigator(s). -25% -
  
  
• Lead the production standard-of-care cellular product derivation is responsible for assay development and implementation of assay protocols. Standard Operating Procedures (SOPs) will be optimized, written, and validated for ongoing and future products. Participate the standard of Care protocols including performing the Autologous Islet Transplant (AIT) program as well as the CD34+ selection program for SCID patients. Protocols include but are not limited to complex advanced Flow Cytometry, operation and maintenance of protocol-specific instruments, and documentation of product data. Techniques include tissue dissection, tissue purification, isolation and preparation of cellular products for re-implantation. Complete product release criteria such as propidium iodide staining for cellular viability, endotoxin quantification, bacterial contamination testing and mycoplasma detection by luminescence as needed. Trains and ensures all personnel maintain optimal performance of aforementioned protocols based on current technology. The project manager will work closely with the Quality Assurance Director to document the training of personnel. Manages and organizes compiled data for presentation purposes to the CCT Program Director. -20% -
  
  
• Project development with investigators and other potential partners. This includes meeting and presenting data to the potential collaborators, budget estimate preparations, SOP development, IND application assistance, and other duties as required by the situation. -10% -
  
  
• Participate in the bone marrow transplant program. Will work directly with customers to develop products by applying guiding principles and existing frameworks to new contexts. -10%
  
  
• Implement a diagnostic testing program by collaborating with the Clinical Pathology Laboratory at MUSC. -Involves maintaining CAP and CLIA compliance and certification, maintaining proficiency testing of key personnel, and processing clinical samples for diagnostic testing and result in entry. -10%
  
  
• Implement a diagnostic testing program for research by providing a shared resource to investigators at MUSC, external private investigators, and industry-sponsored investigators. -Coordinate the receipt and inventory of research samples, plan testing schedule, and provide test results, data analysis, and other requests by the investigator. -10%
  
  
• Work closely with the Financial Director of the Department of Surgery by providing regular budgetary information and record keeping of spending and operating costs. Will be responsible for overseeing all ordering of supplies and reagents in addition to maintaining inventory of such. -5%
  
  
• Work closely with the Quality Assurance Director to maintain and assist with IQ/OQ/PQ on all laboratory equipment. Perform maintenance and calibration work when needed. Participate in the facility Master Validation Plan. Participate in audits by governing agencies and implements new practices based on audit findings and recommendations from QA Director. -5% -
  
  
• Work closely with the Hollings Cancer Center to provide assistance and support for the Cell Evaluation and Therapy Unit (CET). Includes immunomonitoring of cancer patient samples, product and SOP development when needed. Prepare reports and provide program progress to upper management. -5% -
  
  
  
  MUSC Minimum Training and Experience Requirements:
  A bachelor's degree in chemistry, biology, or other natural, life or health care science directly related to the assigned area of research and two years advanced journel-level work experience in a clinical or research setting.
  
  MUSC Physical Requirements:
  (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)
  
  Ability to perform job functions in an upright position. (Frequent)
  Ability to perform job functions in a seated position. (Continuous)
  Ability to perform job functions while walking/mobile. (Frequent)
  Ability to climb, using step stool. (Infrequent)
  Ability to work in temperature extremes (32 - F to 100 - F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent)
  Ability to work in confined/cramped spaces. (Continuous)
  Ability to bend at the waist. (Frequent)
  Ability to twist at the waist. (Frequent)
  Ability to fully use both hands/arms. (Continuous)
  Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent)
  Ability to fully use both legs. (Frequent)
  Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent)
  Ability to maintain good olfactory sensory function/distinction. (Continuous)
  Ability to lift materials up to 20 lbs., unassisted. (Infrequent)
  Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent)
  Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent)
  Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/
  Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent)
  Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent)
  Ability to push/pull file boxes from one location to another at floor level. (Frequent)
  Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent)
  Ability to perform gross motor functions with frequent fine motor movements. (Continuous)
  Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous)
  Ability to match or discriminate between colors, normally. (Continuous)
  Ability to hear and recognize various alarms emitting from work area systems. (Continuous)
  Ability to hear and/or understand conversations. (Continuous)
  Ability to work in a darkroom for processing film, etc. (Continuous)
  Ability to be qualified physically for respirator use, initially and annually. (Continuous)
  
  Additional New Requirements:
  Ability to work rotating shifts as required.
  Ability to work overtime as required.
  Ability to learn and use new processes, tools and equipment as required.
  
  Additional Job Description
  
  The Department of Surgery is dedicated to ensuring the voices of our trainees, staff, faculty, and patients are heard; their thoughts are respected and their feelings are valued. -We pride ourselves on creating an inclusive culture dedicated to helping shape the field of surgery to be more diverse. We value our residents, fellows, faculty, and staff of every race, religion, national origin, sexual orientation, gender identity, and disability. Our goal is to continue to expand our diversity within our talented team, which leads to even more inclusive patient-centered care. Please click on the link below to learn more about our diversity efforts.
  
  https://medicine.musc.edu/departments/surgery/diversity-and-inclusion -
  
  If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
  
  The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
  
  Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here:
  

Keywords: MUSC Health University Hospital, Charleston , UNIV - Research Specialist III - Surgery: Center for Cellular Therapy, Healthcare , Charleston, South Carolina